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CYP2D6 gene polymorphism and apatinib affect the metabolic profile of fluvoxamine

This study aimed 1) to investigate the influence of CYP2D6 variants on the catalyzing of fluvoxamine, and 2) to study the interaction between fluvoxamine and apatinib. An enzymatic reaction system was setup and the kinetic profile of CYP2D6 in metabolizing fluvoxamine was determined. In vivo, drug-d...

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Detalles Bibliográficos
Autores principales: Ye, Zhize, Chen, Bingbing, Gao, Nanyong, Kong, Qihui, Hu, Xiaoqin, Lu, Zhongqiu, Qian, Jianchang, Hu, Guoxin, Cai, Jianping, Wu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479105/
https://www.ncbi.nlm.nih.gov/pubmed/36120346
http://dx.doi.org/10.3389/fphar.2022.985159