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The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies
Osteoarthritis (OA) is the most prevalent joint disease, characterized by the degradation of articular cartilage, synovial inflammation, and changes in periarticular and subchondral bone. Recent studies have reported that Wnt signaling cascades play an important role in the development, growth, and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479192/ https://www.ncbi.nlm.nih.gov/pubmed/36117702 http://dx.doi.org/10.3389/fphys.2022.954454 |
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author | Cheng, Jinchao Li, Min Bai, Ruijun |
author_facet | Cheng, Jinchao Li, Min Bai, Ruijun |
author_sort | Cheng, Jinchao |
collection | PubMed |
description | Osteoarthritis (OA) is the most prevalent joint disease, characterized by the degradation of articular cartilage, synovial inflammation, and changes in periarticular and subchondral bone. Recent studies have reported that Wnt signaling cascades play an important role in the development, growth, and homeostasis of joints. The Wnt signaling cascade should be tightly regulated to maintain the homeostasis of cartilage in either the over-activation or the suppression of Wnt/β-catenin, as this could lead to OA. This review summarizes the role and mechanism of canonical Wnt cascade and noncanonical Wnt cascade experiments in vivo and in vitro. The Wnt cascade is controlled by several agonists and antagonists in the extracellular medium and the cytoplasm. These antagonists and agonists serve as key molecules in drug intervention into the Wnt pathway and may provide potential approaches for the treatment of OA. However, the complexity of the Wnt signaling cascade and the pharmaceutical effects on its mechanism are still not fully understood, which forces us to conduct further research and develop efficient therapeutic approaches to treat OA. |
format | Online Article Text |
id | pubmed-9479192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94791922022-09-17 The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies Cheng, Jinchao Li, Min Bai, Ruijun Front Physiol Physiology Osteoarthritis (OA) is the most prevalent joint disease, characterized by the degradation of articular cartilage, synovial inflammation, and changes in periarticular and subchondral bone. Recent studies have reported that Wnt signaling cascades play an important role in the development, growth, and homeostasis of joints. The Wnt signaling cascade should be tightly regulated to maintain the homeostasis of cartilage in either the over-activation or the suppression of Wnt/β-catenin, as this could lead to OA. This review summarizes the role and mechanism of canonical Wnt cascade and noncanonical Wnt cascade experiments in vivo and in vitro. The Wnt cascade is controlled by several agonists and antagonists in the extracellular medium and the cytoplasm. These antagonists and agonists serve as key molecules in drug intervention into the Wnt pathway and may provide potential approaches for the treatment of OA. However, the complexity of the Wnt signaling cascade and the pharmaceutical effects on its mechanism are still not fully understood, which forces us to conduct further research and develop efficient therapeutic approaches to treat OA. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9479192/ /pubmed/36117702 http://dx.doi.org/10.3389/fphys.2022.954454 Text en Copyright © 2022 Cheng, Li and Bai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Cheng, Jinchao Li, Min Bai, Ruijun The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
title | The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
title_full | The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
title_fullStr | The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
title_full_unstemmed | The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
title_short | The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
title_sort | wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479192/ https://www.ncbi.nlm.nih.gov/pubmed/36117702 http://dx.doi.org/10.3389/fphys.2022.954454 |
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