Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

Opioid tolerance, opioid-induced hyperalgesia during repeated opioid administration, and chronic pain are associated with upregulation of adenylyl cyclase activity. The objective of this study was to test the hypothesis that a reduction in adenylyl cyclase 1 (AC1) activity or expression would attenu...

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Detalles Bibliográficos
Autores principales: Johnson, Kayla, Doucette, Alexis, Edwards, Alexis, Verdi, Aleeya, McFarland, Ryan, Hulke, Shelby, Fowler, Amanda, Watts, Val J., Klein, Amanda H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479488/
https://www.ncbi.nlm.nih.gov/pubmed/36120355
http://dx.doi.org/10.3389/fphar.2022.937741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479488/
https://www.ncbi.nlm.nih.gov/pubmed/36120355
http://dx.doi.org/10.3389/fphar.2022.937741

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