The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity

Forkhead box O transcriptional factors, especially FoxO1 and FoxO3a, play critical roles in physiologic and pathologic immune responses. However, the function of FoxO4, another main member of the FoxO family, in lymphoid cells is still poorly understood. Here, we showed that loss of FoxO4 in T cells...

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Detalles Bibliográficos
Autores principales: Chen, Xiang, Hu, Jia, Wang, Yunfei, Lee, Younghee, Zhao, Xiaohong, Lu, Huiping, Zhu, Gengzhen, Wang, Hui, Jiang, Yu, Liu, Fan, Chen, Yongzhen, Kim, Byung-Seok, Zhou, Qinghua, Liu, Xindong, Wang, Xiaohu, Chang, Seon Hee, Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479610/
https://www.ncbi.nlm.nih.gov/pubmed/36106640
http://dx.doi.org/10.1172/JCI147566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479610/
https://www.ncbi.nlm.nih.gov/pubmed/36106640
http://dx.doi.org/10.1172/JCI147566

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