Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization

Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis which estimates the direct effect of multiple exposures on an outcome using genetic variants as instruments. Mendelian randomization and MVMR are frequently conducted using two‐sample summary data where the asso...

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Detalles Bibliográficos
Autores principales: Sanderson, Eleanor, Spiller, Wes, Bowden, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479726/
https://www.ncbi.nlm.nih.gov/pubmed/34338327
http://dx.doi.org/10.1002/sim.9133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479726/
https://www.ncbi.nlm.nih.gov/pubmed/34338327
http://dx.doi.org/10.1002/sim.9133

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