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Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization
Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis which estimates the direct effect of multiple exposures on an outcome using genetic variants as instruments. Mendelian randomization and MVMR are frequently conducted using two‐sample summary data where the asso...
Autores principales: | Sanderson, Eleanor, Spiller, Wes, Bowden, Jack |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479726/ https://www.ncbi.nlm.nih.gov/pubmed/34338327 http://dx.doi.org/10.1002/sim.9133 |
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