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Replication of alphaviruses requires a pseudoknot that involves the poly(A) tail

Alphaviruses, such as the Sindbis virus and the Chikungunya virus, are RNA viruses with a positive sense single-stranded RNA genome that infect various vertebrates, including humans. A conserved sequence element (CSE) of ∼19 nt in the 3′ noncoding region is important for replication. Despite extensi...

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Detalles Bibliográficos
Autor principal: Olsthoorn, René C.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479738/
https://www.ncbi.nlm.nih.gov/pubmed/35906005
http://dx.doi.org/10.1261/rna.079243.122