Centriole signaling restricts hepatocyte ploidy to maintain liver integrity

Hepatocyte polyploidization is a tightly controlled process that is initiated at weaning and increases with age. The proliferation of polyploid hepatocytes in vivo is restricted by the PIDDosome–P53 axis, but how this pathway is triggered remains unclear. Given that increased hepatocyte ploidy prote...

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Detalles Bibliográficos
Autores principales: Sladky, Valentina C., Akbari, Hanan, Tapias-Gomez, Daniel, Evans, Lauren T., Drown, Chelsea G., Strong, Margaret A., LoMastro, Gina M., Larman, Tatianna, Holland, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480857/
https://www.ncbi.nlm.nih.gov/pubmed/35981754
http://dx.doi.org/10.1101/gad.349727.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480857/
https://www.ncbi.nlm.nih.gov/pubmed/35981754
http://dx.doi.org/10.1101/gad.349727.122

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