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Centriole signaling restricts hepatocyte ploidy to maintain liver integrity
Hepatocyte polyploidization is a tightly controlled process that is initiated at weaning and increases with age. The proliferation of polyploid hepatocytes in vivo is restricted by the PIDDosome–P53 axis, but how this pathway is triggered remains unclear. Given that increased hepatocyte ploidy prote...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480857/ https://www.ncbi.nlm.nih.gov/pubmed/35981754 http://dx.doi.org/10.1101/gad.349727.122 |