The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels

Voltage-gated K(+) (Kv) channels mediate the flow of K(+) across the cell membrane by regulating the conductive state of their activation gate (AG). Several Kv channels display slow C-type inactivation, a process whereby their selectivity filter (SF) becomes less or nonconductive. It has been propos...

Descripción completa

Detalles Bibliográficos
Autores principales: Coonen, Laura, Martinez-Morales, Evelyn, Van De Sande, Dieter V., Snyders, Dirk J., Cortes, D. Marien, Cuello, Luis G., Labro, Alain J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481120/
https://www.ncbi.nlm.nih.gov/pubmed/36112676
http://dx.doi.org/10.1126/sciadv.abn1731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481120/
https://www.ncbi.nlm.nih.gov/pubmed/36112676
http://dx.doi.org/10.1126/sciadv.abn1731

Ejemplares similares