Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies

Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro anticancer screening of target compounds via National cancer institute “NCI” revealed that analogues 1g, 2e, and 2l demonstrated antiproliferative act...

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Detalles Bibliográficos
Autores principales: Saad, Mohamed H., El-Moselhy, Tarek F., S, El-Din, Nabaweya, Mehany, Ahmed B. M., Belal, Amany, Abourehab, Mohammed A. S., Tawfik, Haytham O., El-Hamamsy, Mervat H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481151/
https://www.ncbi.nlm.nih.gov/pubmed/36093880
http://dx.doi.org/10.1080/14756366.2022.2120478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481151/
https://www.ncbi.nlm.nih.gov/pubmed/36093880
http://dx.doi.org/10.1080/14756366.2022.2120478

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