Cargando…

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes virus entry into the cell. Targeting this interaction represents a promising strategy to generate antivirals. By screening a phage-display library of biosynthetic protein sequences build on a rigid alpha-helicoida...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thébault, Stéphanie, Lejal, Nathalie, Dogliani, Alexis, Donchet, Amélie, Urvoas, Agathe, Valerio-Lepiniec, Marie, Lavie, Muriel, Baronti, Cécile, Touret, Franck, Da Costa, Bruno, Bourgon, Clara, Fraysse, Audrey, Saint-Albin-Deliot, Audrey, Morel, Jessica, Klonjkowski, Bernard, de Lamballerie, Xavier, Dubuisson, Jean, Roussel, Alain, Minard, Philippe, Le Poder, Sophie, Meunier, Nicolas, Delmas, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481167/ https://www.ncbi.nlm.nih.gov/pubmed/36067253 http://dx.doi.org/10.1371/journal.ppat.1010799

Ejemplares similares

Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters
por: Bourgon, Clara, et al.
Publicado: (2022)

In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate
por: Touret, Franck, et al.
Publicado: (2022)

Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein
por: Nangola, Sawitree, et al.
Publicado: (2012)

Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)
por: Guellouz, Asma, et al.
Publicado: (2013)

Selection and Characterization of Artificial Proteins Targeting the Tubulin α Subunit
por: Campanacci, Valérie, et al.
Publicado: (2019)

Evaluation of formulations to improve SARS-CoV-2 viability and thermostability after lyophilisation
por: Baronti, C., et al.
Publicado: (2021)

Complete Coding Sequences of Two Dengue Virus Type 2 Strains Isolated from an Outbreak in Burkina Faso in 2016
por: Baronti, Cécile, et al.
Publicado: (2017)

Alpha-helicoidal HEAT-like Repeat Proteins (αRep) Selected as Interactors of HIV-1 Nucleocapsid Negatively Interfere with Viral Genome Packaging and Virus Maturation
por: Hadpech, Sudarat, et al.
Publicado: (2017)

Structural Analysis of the Hanks-Type Protein Kinase YabT From Bacillus subtilis Provides New Insights in its DNA-Dependent Activation
por: Shi, Lei, et al.
Publicado: (2019)

In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5
por: Touret, Franck, et al.
Publicado: (2022)

Specific GFP-binding artificial proteins (αRep): a new tool for in vitro to live cell applications
por: Chevrel, Anne, et al.
Publicado: (2015)

Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
por: Weiss, Anne, et al.
Publicado: (2021)

The Influenza Virus RNA-Polymerase and the Host RNA-Polymerase II: RPB4 Is Targeted by a PB2 Domain That Is Involved in Viral Transcription
por: Morel, Jessica, et al.
Publicado: (2022)

Ligand-induced conformational switch in an artificial bidomain protein scaffold
por: Léger, Corentin, et al.
Publicado: (2019)

Replicative Fitness of a SARS-CoV-2 20I/501Y.V1 Variant from Lineage B.1.1.7 in Human Reconstituted Bronchial Epithelium
por: Touret, Franck, et al.
Publicado: (2021)

Design, synthesis, and characterization of protein origami based on self-assembly of a brick and staple artificial protein pair
por: Moreaud, Laureen, et al.
Publicado: (2023)

Antisense oligonucleotides targeting ORF1b block replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
por: Dhorne-Pollet, Sophie, et al.
Publicado: (2022)

Of chloroquine and COVID-19
por: Touret, Franck, et al.
Publicado: (2020)

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives
por: Barre, Annick, et al.
Publicado: (2021)

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins
por: Gomes, M., et al.
Publicado: (2023)

Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors
por: Campanacci, Valérie, et al.
Publicado: (2022)

How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?
por: Barre, Annick, et al.
Publicado: (2022)

Simple reverse genetics systems for Asian and African Zika viruses
por: Atieh, Thérèse, et al.
Publicado: (2016)

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model
por: Cochin, Maxime, et al.
Publicado: (2022)

Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy
por: Dubuisson, Agathe, et al.
Publicado: (2017)

Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies
por: Lavie, Muriel, et al.
Publicado: (2018)

SARS-CoV-2 Spike Furin Cleavage Site and S2′ Basic Residues Modulate the Entry Process in a Host Cell-Dependent Manner
por: Lavie, Muriel, et al.
Publicado: (2022)

Endothelin increases the proliferation of rat olfactory mucosa cells
por: Bryche, Bertrand, et al.
Publicado: (2019)

Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?
por: Pastorino, Boris, et al.
Publicado: (2020)

Prolonged Infectivity of SARS-CoV-2 in Fomites
por: Pastorino, Boris, et al.
Publicado: (2020)

Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model
por: Driouich, Jean-Sélim, et al.
Publicado: (2023)

An Oil-Based Adjuvant Improves Immune Responses Induced by Canine Adenovirus-Vectored Vaccine in Mice
por: Broutin, Manon, et al.
Publicado: (2023)

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels
por: Cecon, Erika, et al.
Publicado: (2022)

Effect of Chemical Stabilizers on the Thermostability and Infectivity of a Representative Panel of Freeze Dried Viruses
por: Pastorino, Boris, et al.
Publicado: (2015)

Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone
por: Touret, Franck, et al.
Publicado: (2018)

Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples
por: Pastorino, Boris, et al.
Publicado: (2020)

Complete Coding Sequence of Zika Virus from a French Polynesia Outbreak in 2013
por: Baronti, Cécile, et al.
Publicado: (2014)

Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model
por: Attoui, Houssam, et al.
Publicado: (2021)

Dengue Virus Type 3 Infection in Traveler Returning from West Africa
por: Ninove, Laetitia, et al.
Publicado: (2009)

Complete coding sequence of Zika virus from Martinique outbreak in 2015
por: Piorkowski, G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_30u1nn4juufputaj4va24jci4j