A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its activators and effectors. Mammalian cells express four Rag proteins (RagA–D) that form dimers composed of RagA/B bound to R...

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Detalles Bibliográficos
Autores principales: Gollwitzer, Peter, Grützmacher, Nina, Wilhelm, Sabine, Kümmel, Daniel, Demetriades, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481461/
https://www.ncbi.nlm.nih.gov/pubmed/36097072
http://dx.doi.org/10.1038/s41556-022-00976-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481461/
https://www.ncbi.nlm.nih.gov/pubmed/36097072
http://dx.doi.org/10.1038/s41556-022-00976-y

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