Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling

OBJECTIVES: The aim of this study was to simulate the drug–drug interaction (DDI) between ritonavir-boosted atazanavir (ATV/r) and rifampicin (RIF) using physiologically based pharmacokinetic (PBPK) modelling, and to predict suitable dose adjustments for ATV/r for the treatment of people living with...

Descripción completa

Detalles Bibliográficos
Autores principales: Montanha, Maiara Camotti, Fabrega, Francesc, Howarth, Alice, Cottura, Nicolas, Kinvig, Hannah, Bunglawala, Fazila, Lloyd, Andrew, Denti, Paolo, Waitt, Catriona, Siccardi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481493/
https://www.ncbi.nlm.nih.gov/pubmed/34635995
http://dx.doi.org/10.1007/s40262-021-01067-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481493/
https://www.ncbi.nlm.nih.gov/pubmed/34635995
http://dx.doi.org/10.1007/s40262-021-01067-1

Ejemplares similares