Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

Alzheimer’s disease (AD) is the consequence of neuronal death and brain atrophy associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils could be a therapeutic approach to AD. The small molecule EGCG, abundant in green tea, has long been known to disaggregate t...

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Detalles Bibliográficos
Autores principales: Seidler, Paul M., Murray, Kevin A., Boyer, David R., Ge, Peng, Sawaya, Michael R., Hu, Carolyn J., Cheng, Xinyi, Abskharon, Romany, Pan, Hope, DeTure, Michael A., Williams, Christopher K., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481533/
https://www.ncbi.nlm.nih.gov/pubmed/36114178
http://dx.doi.org/10.1038/s41467-022-32951-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481533/
https://www.ncbi.nlm.nih.gov/pubmed/36114178
http://dx.doi.org/10.1038/s41467-022-32951-4

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