Genetic correction of haemoglobin E in an immortalised haemoglobin E/beta-thalassaemia cell line using the CRISPR/Cas9 system

β-thalassaemia is one of the most common genetic blood diseases worldwide with over 300 mutations in the HBB gene affecting red blood cell functions. Recently, advances in genome editing technology have provided a powerful tool for precise genetic correction. Generation of patient-derived induced pl...

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Detalles Bibliográficos
Autores principales: Trakarnsanga, Kongtana, Thongsin, Nontaphat, Metheetrairut, Chanatip, Tipgomut, Chartsiam, Poldee, Saiphon, Wattanapanitch, Methichit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481540/
https://www.ncbi.nlm.nih.gov/pubmed/36114353
http://dx.doi.org/10.1038/s41598-022-19934-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481540/
https://www.ncbi.nlm.nih.gov/pubmed/36114353
http://dx.doi.org/10.1038/s41598-022-19934-7

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