Cargando…

Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants

Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern medicines. Recent studies on the microbial production of benzylisoquinolines have highlighted key biological syntheses towards these natural products. Routes to non-natural benzylisoquinolines have been less explored, p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yu, Subrizi, Fabiana, Carter, Eve M., Sheppard, Tom D., Ward, John M., Hailes, Helen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481557/ https://www.ncbi.nlm.nih.gov/pubmed/36114194 http://dx.doi.org/10.1038/s41467-022-33122-1

Ejemplares similares

Direct Conversion of Hydrazones to Amines using Transaminases
por: Carter, Eve M., et al.
Publicado: (2021)

Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from l-arabinose
por: Bawn, Maria, et al.
Publicado: (2018)

Multienzyme One‐Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids
por: Subrizi, Fabiana, et al.
Publicado: (2021)

Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus
por: Menéndez-Perdomo, Ivette M., et al.
Publicado: (2018)

Aminopolyols from Carbohydrates: Amination of Sugars and Sugar‐Derived Tetrahydrofurans with Transaminases
por: Subrizi, Fabiana, et al.
Publicado: (2019)

The use of tyrosinases in a chemoenzymatic cascade as a peptide ligation strategy
por: Ni, Yeke, et al.
Publicado: (2022)

Enzymatic synthesis of chiral amino‐alcohols by coupling transketolase and transaminase‐catalyzed reactions in a cascading continuous‐flow microreactor system
por: Gruber, Pia, et al.
Publicado: (2017)

BIAdb: A curated database of benzylisoquinoline alkaloids
por: Singla, Deepak, et al.
Publicado: (2010)

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids
por: Ghirga, Francesca, et al.
Publicado: (2017)

Role of the phloem in the biochemistry and ecophysiology of benzylisoquinoline alkaloid metabolism
por: Lee, Eun-Jeong, et al.
Publicado: (2013)

Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases
por: Morris, Jeremy S., et al.
Publicado: (2019)

Engineering Saccharomyces cerevisiae to produce plant benzylisoquinoline alkaloids
por: Han, Jianing, et al.
Publicado: (2021)

Biocatalytic Organic Synthesis of Optically Pure (S)-Scoulerine and Berbine and Benzylisoquinoline Alkaloids
por: Schrittwieser, Joerg H., et al.
Publicado: (2011)

Rational Engineering of (S)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis
por: De Sousa, João P. M., et al.
Publicado: (2023)

Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata
por: Huang, Peng, et al.
Publicado: (2018)

Corrigendum: Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases
por: Morris, Jeremy S., et al.
Publicado: (2019)

Visualization and identification of benzylisoquinoline alkaloids in various nelumbo nucifera tissues
por: Hao, Chenyang, et al.
Publicado: (2023)

Characterisation of a hyperthermophilic transketolase from Thermotoga maritima DSM3109 as a biocatalyst for 7-keto-octuronic acid synthesis
por: Cárdenas-Fernández, Max, et al.
Publicado: (2021)

Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants
por: Hagel, Jillian M., et al.
Publicado: (2015)

Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants
por: Hagel, Jillian M., et al.
Publicado: (2015)

Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
por: Erdmann, Vanessa, et al.
Publicado: (2017)

Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species
por: He, Si-Mei, et al.
Publicado: (2018)

Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus
por: Deng, Xianbao, et al.
Publicado: (2018)

The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids
por: Huang, Peng, et al.
Publicado: (2018)

Benzylisoquinoline Alkaloids from the Stems of Limacia scandens and Their Potential as Autophagy Inhibitors
por: Lee, Hee-Ju, et al.
Publicado: (2022)

De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
por: Han, Jianing, et al.
Publicado: (2023)

Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge enzyme in Macleaya cordata
por: Huang, Peng, et al.
Publicado: (2018)

Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo
por: Dong, Shijuan, et al.
Publicado: (2022)

Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)
por: Menéndez-Perdomo, Ivette M., et al.
Publicado: (2023)

The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants
por: Inoue, Naomi, et al.
Publicado: (2021)

Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus by Disrupting Virus Entry
por: Zhang, Caisheng, et al.
Publicado: (2023)

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production
por: Gao, Meirong, et al.
Publicado: (2023)

Tyrosine phosphorylation and protein degradation control the transcriptional activity of WRKY involved in benzylisoquinoline alkaloid biosynthesis
por: Yamada, Yasuyuki, et al.
Publicado: (2016)

Modulation of benzylisoquinoline alkaloid biosynthesis by heterologous expression of CjWRKY1 in Eschscholzia californica cells
por: Yamada, Yasuyuki, et al.
Publicado: (2017)

Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
por: Vavricka, Christopher J., et al.
Publicado: (2019)

Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids
por: Bu, Junling, et al.
Publicado: (2022)

Evolutionary origin of the NCSI gene subfamily encoding norcoclaurine synthase is associated with the biosynthesis of benzylisoquinoline alkaloids in plants
por: Vimolmangkang, Sornkanok, et al.
Publicado: (2016)

Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo
por: Xu, Dingqiao, et al.
Publicado: (2021)

Chromosome-level genome assembly of Aristolochia contorta provides insights into the biosynthesis of benzylisoquinoline alkaloids and aristolochic acids
por: Cui, Xinyun, et al.
Publicado: (2022)

Topical Formulation of Noscapine, a Benzylisoquinoline Alkaloid, Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions
por: Nourbakhsh, Fahimeh, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_22971vrjmgao4h48gqj7f5bblm