Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling

Serine/threonine phosphorylation of insulin receptor substrate (IRS) proteins is well known to modulate insulin signaling. However, the molecular details of this process have mostly been elusive. While exploring the role of phosphoserines, we have detected a direct link between Tyr-flanking Ser/Thr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeke, András, Takács, Tamás, Sok, Péter, Németh, Krisztina, Kirsch, Klára, Egri, Péter, Póti, Ádám Levente, Bento, Isabel, Tusnády, Gábor E., Reményi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481563/
https://www.ncbi.nlm.nih.gov/pubmed/36114179
http://dx.doi.org/10.1038/s41467-022-32918-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481563/
https://www.ncbi.nlm.nih.gov/pubmed/36114179
http://dx.doi.org/10.1038/s41467-022-32918-5

Ejemplares similares