Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

The Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization in many essential processes. Rac1 binds to WRC at two distinct sites—the A and D sites. Precisely how Rac1 binds and how the binding triggers WRC activation remain unknown. He...

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Detalles Bibliográficos
Autores principales: Ding, Bojian, Yang, Sheng, Schaks, Matthias, Liu, Yijun, Brown, Abbigale J., Rottner, Klemens, Chowdhury, Saikat, Chen, Baoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481577/
https://www.ncbi.nlm.nih.gov/pubmed/36114192
http://dx.doi.org/10.1038/s41467-022-33174-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481577/
https://www.ncbi.nlm.nih.gov/pubmed/36114192
http://dx.doi.org/10.1038/s41467-022-33174-3

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