Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain

The monomeric catalytic domain (residues 1–199) of SARS-CoV-2 main protease (MPro(1-199)) fused to 25 amino acids of its flanking nsp4 region mediates its autoprocessing at the nsp4-MPro(1-199) junction. We report the catalytic activity and the dissociation constants of MPro(1-199) and its analogs w...

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Detalles Bibliográficos
Autores principales: Nashed, Nashaat T., Kneller, Daniel W., Coates, Leighton, Ghirlando, Rodolfo, Aniana, Annie, Kovalevsky, Andrey, Louis, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481597/
https://www.ncbi.nlm.nih.gov/pubmed/36114420
http://dx.doi.org/10.1038/s42003-022-03910-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481597/
https://www.ncbi.nlm.nih.gov/pubmed/36114420
http://dx.doi.org/10.1038/s42003-022-03910-y

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