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Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain
The monomeric catalytic domain (residues 1–199) of SARS-CoV-2 main protease (MPro(1-199)) fused to 25 amino acids of its flanking nsp4 region mediates its autoprocessing at the nsp4-MPro(1-199) junction. We report the catalytic activity and the dissociation constants of MPro(1-199) and its analogs w...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481597/ https://www.ncbi.nlm.nih.gov/pubmed/36114420 http://dx.doi.org/10.1038/s42003-022-03910-y |