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Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

Covalent attachment of ubiquitin (Ub) to proteins is a highly versatile posttranslational modification. Moreover, Ub is not only a modifier but itself is modified by phosphorylation and lysine acetylation. However, the functional consequences of Ub acetylation are poorly understood. By generation an...

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Detalles Bibliográficos
Autores principales: Kienle, Simon Maria, Schneider, Tobias, Stuber, Katrin, Globisch, Christoph, Jansen, Jasmin, Stengel, Florian, Peter, Christine, Marx, Andreas, Kovermann, Michael, Scheffner, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481602/
https://www.ncbi.nlm.nih.gov/pubmed/36114200
http://dx.doi.org/10.1038/s41467-022-33087-1