Cargando…

Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SLCs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rebsamen, Manuele, Girardi, Enrico, Sedlyarov, Vitaly, Scorzoni, Stefania, Papakostas, Konstantinos, Vollert, Manuela, Konecka, Justyna, Guertl, Bettina, Klavins, Kristaps, Wiedmer, Tabea, Superti-Furga, Giulio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481932/ https://www.ncbi.nlm.nih.gov/pubmed/36114003 http://dx.doi.org/10.26508/lsa.202201404

Ejemplares similares

A substrate‐based ontology for human solute carriers
por: Meixner, Eva, et al.
Publicado: (2020)

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs
por: Girardi, Enrico, et al.
Publicado: (2020)

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
por: Girardi, Enrico, et al.
Publicado: (2020)

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking
por: Fauster, Astrid, et al.
Publicado: (2018)

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1
por: Rebsamen, Manuele, et al.
Publicado: (2015)

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection
por: Moskovskich, Anna, et al.
Publicado: (2019)

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
por: Sedlyarov, Vitaly, et al.
Publicado: (2018)

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
por: Heinz, Leonhard X., et al.
Publicado: (2020)

Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools
por: Wiedmer, Tabea, et al.
Publicado: (2022)

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
por: Bigenzahn, Johannes W., et al.
Publicado: (2016)

SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
por: Rebsamen, Manuele, et al.
Publicado: (2015)

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
por: Boeszoermenyi, Andras, et al.
Publicado: (2023)

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
por: Essletzbichler, Patrick, et al.
Publicado: (2023)

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
por: Dixon, Scott J., et al.
Publicado: (2015)

Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
por: Chen, Xudong, et al.
Publicado: (2023)

A time-resolved molecular map of the macrophage response to VSV infection
por: Kandasamy, Richard K, et al.
Publicado: (2016)

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay
por: Hashimoto, Mari, et al.
Publicado: (2018)

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
por: Bensimon, Ariel, et al.
Publicado: (2020)

Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells
por: Pathria, G, et al.
Publicado: (2016)

Metabolomics in Bone Research
por: Fan, Jingzhi, et al.
Publicado: (2021)

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
por: Fauster, A, et al.
Publicado: (2015)

A Preliminary Metabolomic Study of Yorkshire Terrier Enteropathy
por: Galler, Alexandra I., et al.
Publicado: (2022)

In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens
por: César-Razquin, Adrián, et al.
Publicado: (2018)

Current themes in molecular pediatrics: molecular medicine and its applications
por: Superti-Furga, Andrea, et al.
Publicado: (2010)

Cell biology: A key driver of therapeutic innovation
por: Hantschel, Oliver, et al.
Publicado: (2012)

A structure and evolutionary-based classification of solute carriers
por: Ferrada, Evandro, et al.
Publicado: (2022)

Impedance-Based Phenotypic Readout of Transporter Function: A Case for Glutamate Transporters
por: Sijben, Hubert J., et al.
Publicado: (2022)

Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD(+) levels
por: Güldenpfennig, Anka, et al.
Publicado: (2023)

The Connective Tissue Disorder Associated with Recessive Variants in the SLC39A13 Zinc Transporter Gene (Spondylo-Dysplastic Ehlers–Danlos Syndrome Type 3): Insights from Four Novel Patients and Follow-Up on Two Original Cases
por: Kumps, Camille, et al.
Publicado: (2020)

The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment
por: Klavins, Kristaps, et al.
Publicado: (2015)

Targeting allosteric regulatory modules in oncoproteins: “Drugging the Undruggable”
por: Hantschel, Oliver, et al.
Publicado: (2011)

Recent advances in combinatorial drug screening and synergy scoring
por: Pemovska, Tea, et al.
Publicado: (2018)

A guide to plasma membrane solute carrier proteins
por: Pizzagalli, Mattia D., et al.
Publicado: (2020)

Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia
por: Royer-Bertrand, Beryl, et al.
Publicado: (2015)

Sphingolipid-dependent Dscam sorting regulates axon segregation
por: Goyal, Gaurav, et al.
Publicado: (2019)

SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer
por: Kim, Myeong Jin, et al.
Publicado: (2023)

Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
por: Dvorak, Vojtech, et al.
Publicado: (2023)

Diet supporting therapy for inflammatory bowel diseases
por: Kikut, Justyna, et al.
Publicado: (2021)

IFITs: Emerging Roles as Key Anti-Viral Proteins
por: Vladimer, Gregory I., et al.
Publicado: (2014)

Clouds over IMD? Perspectives for inherited metabolic diseases in adults from a retrospective cohort study in two Swiss adult metabolic clinics
por: Gariani, Karim, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1v01o7s51ski71gkm5nbslt0mg