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ALS-linked loss of Cyclin-F function affects HSP90
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)(Cyclin-F) which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in CCNF encoding for...
Autores principales: | Siebert, Alexander, Gattringer, Vanessa, Weishaupt, Jochen H, Behrends, Christian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481933/ https://www.ncbi.nlm.nih.gov/pubmed/36114006 http://dx.doi.org/10.26508/lsa.202101359 |
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