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Knowledge-guided deep learning models of drug toxicity improve interpretation
In drug development, a major reason for attrition is the lack of understanding of cellular mechanisms governing drug toxicity. The black-box nature of conventional classification models has limited their utility in identifying toxicity pathways. Here we developed DTox (deep learning for toxicology),...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481960/ https://www.ncbi.nlm.nih.gov/pubmed/36124309 http://dx.doi.org/10.1016/j.patter.2022.100565 |