PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis

Profilin 4 (Pfn4) is expressed during spermiogenesis and localizes to the acrosome-acroplaxome-manchette complex. Here, we generated PFN4-deficient mice, with sperm displaying severe impairment in manchette formation. Interestingly, HOOK1 staining suggests that the perinuclear ring is established; h...

Descripción completa

Detalles Bibliográficos
Autores principales: Umer, Naila, Phadke, Sharang, Shakeri, Farhad, Arévalo, Lena, Lohanadan, Keerthika, Kirfel, Gregor, Sylvester, Marc, Buness, Andreas, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481974/
https://www.ncbi.nlm.nih.gov/pubmed/35950913
http://dx.doi.org/10.1242/dev.200499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481974/
https://www.ncbi.nlm.nih.gov/pubmed/35950913
http://dx.doi.org/10.1242/dev.200499

Ejemplares similares