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PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis

Profilin 4 (Pfn4) is expressed during spermiogenesis and localizes to the acrosome-acroplaxome-manchette complex. Here, we generated PFN4-deficient mice, with sperm displaying severe impairment in manchette formation. Interestingly, HOOK1 staining suggests that the perinuclear ring is established; h...

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Detalles Bibliográficos
Autores principales:	Umer, Naila, Phadke, Sharang, Shakeri, Farhad, Arévalo, Lena, Lohanadan, Keerthika, Kirfel, Gregor, Sylvester, Marc, Buness, Andreas, Schorle, Hubert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481974/ https://www.ncbi.nlm.nih.gov/pubmed/35950913 http://dx.doi.org/10.1242/dev.200499

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