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Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen
BACKGROUND & AIMS: HBV persistence is maintained by both an episomal covalently closed circular (ccc)DNA reservoir and genomic integration of HBV DNA fragments. While cccDNA transcription is regulated by Cullin4A-DDB1-HBx-mediated degradation of the SMC5/6 complex, HBsAg expression from integran...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482114/ https://www.ncbi.nlm.nih.gov/pubmed/36124123 http://dx.doi.org/10.1016/j.jhepr.2022.100551 |