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Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen

BACKGROUND & AIMS: HBV persistence is maintained by both an episomal covalently closed circular (ccc)DNA reservoir and genomic integration of HBV DNA fragments. While cccDNA transcription is regulated by Cullin4A-DDB1-HBx-mediated degradation of the SMC5/6 complex, HBsAg expression from integran...

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Detalles Bibliográficos
Autores principales:	Qu, Bingqian, Nebioglu, Firat, Leuthold, Mila M., Ni, Yi, Mutz, Pascal, Beneke, Jürgen, Erfle, Holger, Vondran, Florian W.R., Bartenschlager, Ralf, Urban, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482114/ https://www.ncbi.nlm.nih.gov/pubmed/36124123 http://dx.doi.org/10.1016/j.jhepr.2022.100551

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