Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration

BACKGROUND: Dysfunctional humoral and cellular innate immunity are key components in the development and progression of age-related macular degeneration (AMD). Specifically, chronically activated microglia and their disturbed regulatory system contribute to retinal degeneration. Galectin-3, a β-gala...

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Detalles Bibliográficos
Autores principales: Tabel, Mona, Wolf, Anne, Szczepan, Manon, Xu, Heping, Jägle, Herbert, Moehle, Christoph, Chen, Mei, Langmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482176/
https://www.ncbi.nlm.nih.gov/pubmed/36115971
http://dx.doi.org/10.1186/s12974-022-02589-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482176/
https://www.ncbi.nlm.nih.gov/pubmed/36115971
http://dx.doi.org/10.1186/s12974-022-02589-6

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