Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

BACKGROUND: Although CD4(+) memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infection, the depleted nucleotide pool and high dUTP levels in monocyte derived m...

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Detalles Bibliográficos
Autores principales: Cui, Junru, Meshesha, Mesfin, Churgulia, Natela, Merlo, Christian, Fuchs, Edward, Breakey, Jennifer, Jones, Joyce, Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482235/
https://www.ncbi.nlm.nih.gov/pubmed/36114511
http://dx.doi.org/10.1186/s12977-022-00607-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482235/
https://www.ncbi.nlm.nih.gov/pubmed/36114511
http://dx.doi.org/10.1186/s12977-022-00607-2

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