iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Dysregulation of the ERBB/EGFR signalling pathway causes multiple types of cancer. Accordingly, ADAM17, the primary shedding enzyme that releases and activates ERBB ligands, is tightly regulated. It has recently become clear that iRhom proteins, inactive members of the rhomboid-like superfamily, are...

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Detalles Bibliográficos
Autores principales: Sieber, Boris, Lu, Fangfang, Stribbling, Stephen M., Grieve, Adam G., Ryan, Anderson J., Freeman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482348/
https://www.ncbi.nlm.nih.gov/pubmed/35971826
http://dx.doi.org/10.1242/jcs.259949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482348/
https://www.ncbi.nlm.nih.gov/pubmed/35971826
http://dx.doi.org/10.1242/jcs.259949

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