Preclinical Pharmacokinetics, Tissue Distribution and in vitro Metabolism of FHND6091, a Novel Oral Proteasome Inhibitor

INTRODUCTION: FHND6091, a novel N-capped dipeptidyl boronic acid proteasome inhibitor with promising pharmacological properties, entirely converted into active form FHND6081 under physiological conditions. The proteasome, a key component of the ubiquitin-proteasome pathway (UPP), has emerged as a va...

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Detalles Bibliográficos
Autores principales: Yang, Xu, Liu, Amin, Yang, Lin, Wen, Tiantian, Wang, Jia, Shi, Jingmiao, Zhou, Hui, Chen, Zhimeng, Lei, Meng, Zhu, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482464/
https://www.ncbi.nlm.nih.gov/pubmed/36124108
http://dx.doi.org/10.2147/DDDT.S371020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482464/
https://www.ncbi.nlm.nih.gov/pubmed/36124108
http://dx.doi.org/10.2147/DDDT.S371020

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