Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

The molecular mechanisms underlying lethal castration-resistant prostate cancer remain poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine the temporal aspects of resistance, we analyze tumor heterogeneity in needle biopsies collected before and after treatmen...

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Detalles Bibliográficos
Autores principales: Marklund, Maja, Schultz, Niklas, Friedrich, Stefanie, Berglund, Emelie, Tarish, Firas, Tanoglidi, Anna, Liu, Yao, Bergenstråhle, Ludvig, Erickson, Andrew, Helleday, Thomas, Lamb, Alastair D., Sonnhammer, Erik, Lundeberg, Joakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482614/
https://www.ncbi.nlm.nih.gov/pubmed/36115838
http://dx.doi.org/10.1038/s41467-022-33069-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482614/
https://www.ncbi.nlm.nih.gov/pubmed/36115838
http://dx.doi.org/10.1038/s41467-022-33069-3

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