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Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
The molecular mechanisms underlying lethal castration-resistant prostate cancer remain poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine the temporal aspects of resistance, we analyze tumor heterogeneity in needle biopsies collected before and after treatmen...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482614/ https://www.ncbi.nlm.nih.gov/pubmed/36115838 http://dx.doi.org/10.1038/s41467-022-33069-3 |