The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1

Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown. In this study, we report that SPOP physically interacts with,...

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Detalles Bibliográficos
Autores principales: Wei, Chunli, Liu, Yun, Liu, Xiaoyan, Cheng, Jingliang, Fu, Jiewen, Xiao, Xiuli, Moses, Robb E., Li, Xiaotao, Fu, Junjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482615/
https://www.ncbi.nlm.nih.gov/pubmed/36115849
http://dx.doi.org/10.1038/s41420-022-01182-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482615/
https://www.ncbi.nlm.nih.gov/pubmed/36115849
http://dx.doi.org/10.1038/s41420-022-01182-3

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