Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Oncogenic RAS mutations are common in multiple myeloma (MM), an incurable malignancy of plasma cells. However, the mechanisms of pathogenic RAS signaling in this disease remain enigmatic and difficult to inhibit therapeutically. We employ an unbiased proteogenomic approach to dissect RAS signaling i...

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Detalles Bibliográficos
Autores principales: Yang, Yandan, Bolomsky, Arnold, Oellerich, Thomas, Chen, Ping, Ceribelli, Michele, Häupl, Björn, Wright, George W., Phelan, James D., Huang, Da Wei, Lord, James W., Van Winkle, Callie K., Yu, Xin, Wisniewski, Jan, Wang, James Q., Tosto, Frances A., Beck, Erin, Wilson, Kelli, McKnight, Crystal, Travers, Jameson, Klumpp-Thomas, Carleen, Smith, Grace A., Pittaluga, Stefania, Maric, Irina, Kazandjian, Dickran, Thomas, Craig J., Young, Ryan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482638/
https://www.ncbi.nlm.nih.gov/pubmed/36115844
http://dx.doi.org/10.1038/s41467-022-33142-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482638/
https://www.ncbi.nlm.nih.gov/pubmed/36115844
http://dx.doi.org/10.1038/s41467-022-33142-x

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