SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

SPACA6 is a sperm-expressed surface protein that is critical for gamete fusion during mammalian sexual reproduction. Despite this fundamental role, little is known about how SPACA6 specifically functions. We elucidated the crystal structure of the SPACA6 ectodomain at 2.2-Å resolution, revealing a t...

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Detalles Bibliográficos
Autores principales: Vance, Tyler D. R., Yip, Patrick, Jiménez, Elisabet, Li, Sheng, Gawol, Diana, Byrnes, James, Usón, Isabel, Ziyyat, Ahmed, Lee, Jeffrey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482655/
https://www.ncbi.nlm.nih.gov/pubmed/36115925
http://dx.doi.org/10.1038/s42003-022-03883-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482655/
https://www.ncbi.nlm.nih.gov/pubmed/36115925
http://dx.doi.org/10.1038/s42003-022-03883-y

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