Cargando…

SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

SPACA6 is a sperm-expressed surface protein that is critical for gamete fusion during mammalian sexual reproduction. Despite this fundamental role, little is known about how SPACA6 specifically functions. We elucidated the crystal structure of the SPACA6 ectodomain at 2.2-Å resolution, revealing a t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vance, Tyler D. R., Yip, Patrick, Jiménez, Elisabet, Li, Sheng, Gawol, Diana, Byrnes, James, Usón, Isabel, Ziyyat, Ahmed, Lee, Jeffrey E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482655/ https://www.ncbi.nlm.nih.gov/pubmed/36115925 http://dx.doi.org/10.1038/s42003-022-03883-y

Ejemplares similares

Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion
por: Barbaux, Sandrine, et al.
Publicado: (2020)

The cell biology of fertilization: Gamete attachment and fusion
por: Siu, Karen K., et al.
Publicado: (2021)

Expression profile of SPACA5/Spaca5 in spermatogenesis and transitional cell carcinoma of the bladder
por: Zhang, Xiao-Yue, et al.
Publicado: (2016)

The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization
por: Fujihara, Yoshitaka, et al.
Publicado: (2021)

The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish
por: Binner, Mirjam I., et al.
Publicado: (2022)

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm−oocyte fusion in mice
por: Noda, Taichi, et al.
Publicado: (2020)

Virus and eukaryote fusogen superfamilies
por: Vance, Tyler D.R., et al.
Publicado: (2020)

SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules
por: Gui, Miao, et al.
Publicado: (2022)

Partial Sperm beta1 Integrin Subunit Deletion Proves Its Involvement in Mouse Gamete Adhesion/Fusion
por: Barraud-Lange, Virginie, et al.
Publicado: (2020)

Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion
por: Inoue, Naokazu, et al.
Publicado: (2021)

Selection and Conservation of Gametes and Embryos for Improving Assisted Reproductive Technologies
por: Gambini, Andrés, et al.
Publicado: (2023)

Spermatogenic cell-specific SPACA4 is essential for efficient sperm-zona pellucida binding in vitro
por: Chen, Lin, et al.
Publicado: (2023)

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions
por: Mittal, Nidhi, et al.
Publicado: (2021)

Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
por: Zhang, Jun, et al.
Publicado: (2021)

ROLE OF THE GAMETE MEMBRANES IN FERTILIZATION IN SACCOGLOSSUS KOWALEVSKII (ENTEROPNEUSTA) : II. Zygote Formation by Gamete Membrane Fusion
por: Colwin, Laura Hunter, et al.
Publicado: (1963)

Fusexins, HAP2/GCS1 and Evolution of Gamete Fusion
por: Brukman, Nicolas G., et al.
Publicado: (2022)

Novel requirements for HAP2-mediated gamete fusion in Tetrahymena
por: Pinello, J.F., et al.
Publicado: (2023)

Ectodomain Pulling Combines with Fusion Peptide Inserting to Provide Cooperative Fusion for Influenza Virus and HIV
por: Akimov, Sergey A., et al.
Publicado: (2020)

An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels
por: Ase, Ariel R., et al.
Publicado: (2019)

Novel glycopolypeptide synthesis induced by gametic cell fusion in Chlamydomonas reinhardtii
Publicado: (1978)

MORPHOLOGY OF GAMETE MEMBRANE FUSION AND OF SPERM ENTRY INTO OOCYTES OF THE SEA URCHIN
por: Franklin, Luther E.
Publicado: (1965)

Evidence for involvement of metalloendoproteases in a step in sea urchin gamete fusion
Publicado: (1988)

Fusion surface structure, function, and dynamics of gamete fusogen HAP2
por: Feng, Juan, et al.
Publicado: (2018)

Gamete pysiology
Publicado: (1990)

Gametes—The Spermatozoon
por: Franks, Stephen
Publicado: (1997)

Relative Stabilities of Conserved and Non-Conserved Structures in the OB-Fold Superfamily
por: Guardino, Kaitlyn M., et al.
Publicado: (2009)

Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain
por: Kalbermatter, David, et al.
Publicado: (2020)

Activation for cell fusion in Chlamydomonas: analysis of wild-type gametes and nonfusing mutants
Publicado: (1982)

Cell fusion as the formation mechanism of unreduced gametes in the gynogenetic diploid hybrid fish
por: Wang, Jing, et al.
Publicado: (2016)

Alternative splicing of the Izumo1 gene ensures triggering gamete fusion in mice
por: Saito, Takako, et al.
Publicado: (2019)

Sperm IZUMO1-Dependent Gamete Fusion Influences Male Fertility in Mice
por: Saito, Takako, et al.
Publicado: (2019)

HAP2-Mediated Gamete Fusion: Lessons From the World of Unicellular Eukaryotes
por: Pinello, Jennifer F., et al.
Publicado: (2022)

Cryopreservation of Gametes and Embryos and Their Molecular Changes
por: Estudillo, Enrique, et al.
Publicado: (2021)

Gametic differentiation in Chlamydomonas reinhardtii. I. Production of gametes and their fine structure
Publicado: (1975)

Aging gametes; their biology and pathology
Publicado: (1975)

Postmortem Collection of Gametes for the Conservation of Endangered Mammals: A Review of the Current State-of-the-Art
por: Huijsmans, Tim E. R. G., et al.
Publicado: (2023)

Positional relationship between the gamete fusion site and the first division plane in the rice zygote
por: Nakajima, Keisuke, et al.
Publicado: (2010)

The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein
por: Fédry, Juliette, et al.
Publicado: (2017)

Expanded carrier screening in gamete donors of Venezuela
por: Urbina, Maria Teresa, et al.
Publicado: (2017)

Reimagining disability: the screening of donor gametes and embryos in IVF
por: Karpin, Isabel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9gmhi52mdgedad7g9ncagb5a8d