Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system

INTRODUCTION: Metformin is currently first line therapy for type 2 diabetes (T2D). The mechanism of action of metformin involves activation of AMP-activated protein kinase (AMPK) to enhance mitochondrial function (for example, biogenesis, refurbishment and dynamics) and autophagy. Many neurodegenera...

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Detalles Bibliográficos
Autores principales: Demaré, Sarah, Kothari, Asha, Calcutt, Nigel A., Fernyhough, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482886/
https://www.ncbi.nlm.nih.gov/pubmed/33161784
http://dx.doi.org/10.1080/14737175.2021.1847645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482886/
https://www.ncbi.nlm.nih.gov/pubmed/33161784
http://dx.doi.org/10.1080/14737175.2021.1847645

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