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Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system

INTRODUCTION: Metformin is currently first line therapy for type 2 diabetes (T2D). The mechanism of action of metformin involves activation of AMP-activated protein kinase (AMPK) to enhance mitochondrial function (for example, biogenesis, refurbishment and dynamics) and autophagy. Many neurodegenera...

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Detalles Bibliográficos
Autores principales:	Demaré, Sarah, Kothari, Asha, Calcutt, Nigel A., Fernyhough, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482886/ https://www.ncbi.nlm.nih.gov/pubmed/33161784 http://dx.doi.org/10.1080/14737175.2021.1847645

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