Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation

2-Hydroxyglutarate (2HG) overproducing tumors arise in a number of tissues, including the kidney. The tumorigenesis resulting from overproduced 2HG has been attributed to the ability of 2HG alter gene expression by inhibiting α-ketoglutarate (αKG)-dependent dioxygenases, including Ten-eleven-Translo...

Descripción completa

Detalles Bibliográficos
Autores principales: Taub, Mary, Mahmoudzadeh, Nader H., Tennessen, Jason M., Sudarshan, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483015/
https://www.ncbi.nlm.nih.gov/pubmed/36133305
http://dx.doi.org/10.3389/fendo.2022.932286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483015/
https://www.ncbi.nlm.nih.gov/pubmed/36133305
http://dx.doi.org/10.3389/fendo.2022.932286

Ejemplares similares