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Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation

2-Hydroxyglutarate (2HG) overproducing tumors arise in a number of tissues, including the kidney. The tumorigenesis resulting from overproduced 2HG has been attributed to the ability of 2HG alter gene expression by inhibiting α-ketoglutarate (αKG)-dependent dioxygenases, including Ten-eleven-Translo...

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Detalles Bibliográficos
Autores principales:	Taub, Mary, Mahmoudzadeh, Nader H., Tennessen, Jason M., Sudarshan, Sunil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483015/ https://www.ncbi.nlm.nih.gov/pubmed/36133305 http://dx.doi.org/10.3389/fendo.2022.932286

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