Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Drug-induced cardiotoxicity is a common side effect of drugs in clinical use or under postmarket surveillance and is commonly due to off-target interactions with the cardiac human-ether-a-go-go-related (hERG) potassium channel. Therefore, prioritizing drug candidates based on their hERG blocking pot...

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Detalles Bibliográficos
Autores principales: Delre, Pietro, Lavado, Giovanna J., Lamanna, Giuseppe, Saviano, Michele, Roncaglioni, Alessandra, Benfenati, Emilio, Mangiatordi, Giuseppe Felice, Gadaleta, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483173/
https://www.ncbi.nlm.nih.gov/pubmed/36133824
http://dx.doi.org/10.3389/fphar.2022.951083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483173/
https://www.ncbi.nlm.nih.gov/pubmed/36133824
http://dx.doi.org/10.3389/fphar.2022.951083

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