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A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid

Hypothiocyanous acid (HOSCN) is an antimicrobial oxidant produced from hydrogen peroxide and thiocyanate anions by heme peroxidases in secretory fluids such as in the human respiratory tract. Some respiratory tract pathogens display tolerance to this oxidant, which suggests that there might be thera...

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Detalles Bibliográficos
Autores principales: Shearer, Heather L., Pace, Paul E., Paton, James C., Hampton, Mark B., Dickerhof, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483559/
https://www.ncbi.nlm.nih.gov/pubmed/35952759
http://dx.doi.org/10.1016/j.jbc.2022.102359