Temperature-dependent hydrogen deuterium exchange shows impact of analog binding on adenosine deaminase flexibility but not embedded thermal networks

The analysis of hydrogen deuterium exchange by mass spectrometry as a function of temperature and mutation has emerged as a generic and efficient tool for the spatial resolution of protein networks that are proposed to function in the thermal activation of catalysis. In this work, we extend temperat...

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Detalles Bibliográficos
Autores principales: Gao, Shuaihua, Zhang, Wenju, Barrow, Samuel L., Iavarone, Anthony T., Klinman, Judith P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483566/
https://www.ncbi.nlm.nih.gov/pubmed/35933011
http://dx.doi.org/10.1016/j.jbc.2022.102350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483566/
https://www.ncbi.nlm.nih.gov/pubmed/35933011
http://dx.doi.org/10.1016/j.jbc.2022.102350

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