A p53 transcriptional signature in primary and metastatic cancers derived using machine learning

The tumor suppressor gene, TP53, has the highest rate of mutation among all genes in human cancer. This transcription factor plays an essential role in the regulation of many cellular processes. Mutations in TP53 result in loss of wild-type p53 function in a dominant negative manner. Although TP53 i...

Descripción completa

Detalles Bibliográficos
Autores principales: Keshavarz-Rahaghi, Faeze, Pleasance, Erin, Kolisnik, Tyler, Jones, Steven J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483853/
https://www.ncbi.nlm.nih.gov/pubmed/36134028
http://dx.doi.org/10.3389/fgene.2022.987238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483853/
https://www.ncbi.nlm.nih.gov/pubmed/36134028
http://dx.doi.org/10.3389/fgene.2022.987238

Ejemplares similares