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Cuprizone-induced Demyelination in Mouse Brain is not due to Depletion of Copper

The cuprizone (CPZ) model allows the study of the biochemical processes underlying nonautoimmune-mediated demyelination, remyelination, and chronic white matter disease progression. CPZ is a copper (Cu) chelator that chiefly causes oligodendrocyte apoptosis in the corpus callosum and cerebellum when...

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Detalles Bibliográficos
Autores principales: Morgan, Megan L., Teo, Wulin, Hernandez, Yda, Brideau, Craig, Cummins, Karen, Kuipers, Hedwich F., Stys, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483969/
https://www.ncbi.nlm.nih.gov/pubmed/36114624
http://dx.doi.org/10.1177/17590914221126367