Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease

BACKGROUND: Huntington’s disease (HD) is a genetic neurodegenerative disease caused by trinucleotide repeat (CAG) expansions in the human HTT gene encoding the huntingtin protein (Htt) with an expanded polyglutamine tract. OBJECTIVE: HD models from yeast to transgenic mice have investigated proteins...

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Detalles Bibliográficos
Autores principales: Podvin, Sonia, Rosenthal, Sara Brin, Poon, William, Wei, Enlin, Fisch, Kathleen M., Hook, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484122/
https://www.ncbi.nlm.nih.gov/pubmed/35871359
http://dx.doi.org/10.3233/JHD-220538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484122/
https://www.ncbi.nlm.nih.gov/pubmed/35871359
http://dx.doi.org/10.3233/JHD-220538

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