Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease

Since the discovery of the mutation causing Huntington’s disease (HD) in 1993, it has been debated whether an expanded polyglutamine (polyQ) stretch affects the properties of the huntingtin (HTT) protein and thus contributes to the pathological mechanisms responsible for HD. Here we review the curre...

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Detalles Bibliográficos
Autores principales: Seefelder, Manuel, Klein, Fabrice A.C., Landwehrmeyer, Bernhard, Fernández-Busnadiego, Rubén, Kochanek, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484127/
https://www.ncbi.nlm.nih.gov/pubmed/35871360
http://dx.doi.org/10.3233/JHD-220543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484127/
https://www.ncbi.nlm.nih.gov/pubmed/35871360
http://dx.doi.org/10.3233/JHD-220543

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